Overview
Selank is a synthetic peptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is a heptapeptide analog of the immunomodulatory peptide tuftsin with an added Pro-Gly-Pro sequence for stability. It is approved in Russia as a nasal spray for anxiety and cognitive enhancement. It is notable for its anxiolytic effects without sedation or addiction potential.
Mechanism of action
Selank modulates the expression of brain-derived neurotrophic factor (BDNF) and affects the balance of T-helper cell cytokines. It influences the GABAergic system (similar to benzodiazepines but without sedation or dependence), modulates serotonin and dopamine metabolism, and enhances enkephalin stability. The immunomodulatory effects come from its tuftsin backbone, which stimulates phagocytosis.
Dosing protocols
| Purpose | Route | Dosage | Frequency | Notes |
|---|---|---|---|---|
| anxiety / cognitive enhancement | nasal | 250–500 mcg | 2-3x daily | Nasal spray is the most common route. Can also be administered subcutaneously. Cycles of 2-4 weeks with 1-2 week breaks. |
Dosing information is for educational purposes only. Consult a qualified healthcare professional before using any peptide.
Research summary
Russian clinical studies show significant anxiolytic effects comparable to benzodiazepines but without sedation, cognitive impairment, or addiction. Gene expression studies demonstrate upregulation of 36 genes related to GABAergic neurotransmission. Shown to enhance memory consolidation in animal models, stabilize enkephalins, and modulate IL-6 expression. Approved in Russia for generalized anxiety disorder (nasal spray formulation).
Side effects
Side effects vary by individual. This is not an exhaustive list. Report unusual symptoms to a healthcare professional.
Common stacks
Peptides commonly paired with Selank for synergistic effects.
Legal status
Approved in Russia as an anxiolytic nasal spray. Not FDA-approved. Available as a research peptide in the US. No regulatory scheduling.
Where to get it
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