Palmitoyl Tripeptide-38

Palmitoyl Tripeptide-38 is a matrikine-mimetic signal peptide derived from tripeptide KMK found naturally in collagen VI and laminin. It is a palmitoylated lipopeptide used in anti-aging cosmeceutical formulations for its ability to simultaneously stimulate six key components of the dermal extracellular matrix, making it one of the most comprehensive skin-regenerating peptides available.

Palmitoyl Tripeptide-38 acts as a matrikine mimic, sending biological signals to dermal fibroblasts to upregulate synthesis of collagen I, II, and IV, fibronectin, hyaluronic acid, and laminin-5. The palmitoyl fatty acid chain enhances skin penetration through the lipophilic stratum corneum. Once in the dermis, the peptide activates fibroblast collagen-synthesis pathways and supports ECM remodeling at the dermal-epidermal junction. It also modulates wound repair signaling and promotes tissue regeneration without irritating the epidermis.

In vitro studies confirm stimulation of six major ECM proteins simultaneously. A 2-month clinical study using 2% active concentration showed up to 31% reduction in wrinkle depth in women. A face serum study combining Palmitoyl Tripeptide-38 with hydrolyzed hyaluronic acid and bakuchiol demonstrated significant improvements in skin quality scores. All evidence is cosmetic/in vitro; no published RCTs as of 2026.

Peptides commonly paired with Palmitoyl Tripeptide-38 for synergistic effects.