Overview
GHK-Cu is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. It declines with age (from ~200 ng/mL at age 20 to ~80 ng/mL at age 60). It promotes skin remodeling, wound healing, and has demonstrated anti-aging properties in both topical and injectable forms.
Mechanism of action
GHK-Cu modulates expression of over 4,000 genes, shifting the gene expression pattern of older cells toward a younger, healthier phenotype. It stimulates collagen and elastin synthesis, promotes glycosaminoglycan production, activates stem cells, and has potent anti-inflammatory and antioxidant effects via copper delivery.
Dosing protocols
| Purpose | Route | Dosage | Frequency | Notes |
|---|---|---|---|---|
| skin rejuvenation | topical | 1–3 % | twice daily | Apply to clean skin. Available in creams and serums. |
| systemic anti-aging | subcutaneous | 1–2 mg | daily | 4-6 week cycles. Often combined with BPC-157. |
Dosing information is for educational purposes only. Consult a qualified healthcare professional before using any peptide.
Research summary
Peer-reviewed studies demonstrate: 70% increase in collagen synthesis, improved wound healing (comparable to vitamin A retinoic acid), increased hair follicle size, and gene expression changes associated with tissue remodeling. Topical formulations are well-established in cosmeceuticals. Injectable use is less studied.
Side effects
Side effects vary by individual. This is not an exhaustive list. Report unusual symptoms to a healthcare professional.
Common stacks
Peptides commonly paired with GHK-Cu for synergistic effects.
Legal status
Available as a cosmetic ingredient (topical) and research peptide (injectable). Not FDA-regulated as a drug when sold for cosmetic use.
Where to get it
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