Overview
Kisspeptin-10 is the shortest bioactive fragment of kisspeptin, a neuropeptide that plays a central role in the initiation of puberty and regulation of the reproductive axis. It is the master upstream regulator of gonadotropin-releasing hormone (GnRH), making it a key switch in the hormonal cascade that controls testosterone, estrogen, LH, and FSH production. It is being studied as a diagnostic tool and therapeutic for reproductive disorders.
Mechanism of action
Kisspeptin-10 binds to the KISS1R (GPR54) receptor on GnRH neurons in the hypothalamus, triggering the release of GnRH. This initiates the hypothalamic-pituitary-gonadal (HPG) axis cascade: GnRH stimulates LH and FSH release from the pituitary, which in turn stimulates testosterone/estrogen production in the gonads. Kisspeptin acts as the 'master switch' of this entire system — without kisspeptin signaling, puberty does not occur.
Dosing protocols
| Purpose | Route | Dosage | Frequency | Notes |
|---|---|---|---|---|
| hormonal optimization / LH stimulation | subcutaneous | 100–500 mcg | 1-2x daily | Limited community dosing data. Clinical studies use IV bolus or continuous infusion. Subcutaneous is common in biohacking contexts. Short cycles only. |
Dosing information is for educational purposes only. Consult a qualified healthcare professional before using any peptide.
Research summary
Clinical studies demonstrate that kisspeptin-10 administration acutely increases LH and testosterone levels in men. Dhillo et al. (2005, JCEM) showed that IV kisspeptin-10 potently stimulated gonadotropin release in healthy men. Studies in women show stimulation of LH pulses. Being investigated as a diagnostic test for pubertal disorders and as a fertility treatment. Imperial College London leads clinical research. Safety data from clinical trials is favorable — well-tolerated with predictable hormonal responses.
Side effects
Side effects vary by individual. This is not an exhaustive list. Report unusual symptoms to a healthcare professional.
Common stacks
Peptides commonly paired with Kisspeptin-10 for synergistic effects.
Legal status
Not FDA-approved. In clinical investigation at multiple academic centers. Available as a research peptide. Not scheduled.
Where to get it
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